By modifying endothelial cell signaling, INGENIA technology provides breakthrough vascular therapeutics.

Based on our deep understanding of endothelial biology, we found a unique way to halt, recover, and restore abnormal blood vessels by modifying a clinically validated signaling pathway. Our target pathway is required for blood vessel development and has a critical role in the control of vascular stability. The pathway controls vascular permeability, inflammation, and pathological angiogenic responses.

Diseases that are caused by aging and defective blood vessels are very diverse and often challenging to manage or treat.

Inflamed and leaky blood vessels are found in many human diseases and conditions, including vascular complications of diabetes, retinal diseases, inflammatory diseases, cancer, and vasculitis. The re-establishment of a structurally and functionally stable vasculature would be beneficial to treat and manage these disease and conditions.

Defective Blood Vessels

Eye Diseases

Brain Diseases

Cardio Vascular Diseases

Infectious & Inflammatory Diseases

Kidney Diseases

Cancer

Neuropathy

Restoring Defective Blood Vessel by INGENIA Technology

Leaky, inflamed, & angiogenic vessel (Disease)

• Inflammation
• Hypoxia
• Angiogenesis

Technology

Non-leaky & healthy vessel

• Inflammation
• Hypoxia
• Angiogenesis

• Red blood cell
• T Lymphocyte
• Neutrophil
• Macrophage
• Pericyte
• Endothelial